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Despite the intense inflammatory response generated, CF patients are paradoxically unable to overcome the infection (Bals et al., 1999)

Notably, insufficient sample sizes reduce statistical power, hindering the detection of TCMs potential efficacy as an adjuvant therapy and increasing the risk of false-positive or false-negative results

(3) Achieving therapeutic concentrations in relevant tissues, such as the brain or endothelium, without inducing systemic toxicity remains a significant hurdle