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This ligand-free state shows a partially activated receptor with TM6 moving outward, but the ECD and peptide-binding pocket differ from the fully active state

PCT is an Important Part of the Solution For Critically Ill Patients: Antibiotic therapy is of great importance Prolonged duration is associated with development of antimicrobial resistance PCT-guided antibiotic therapy reduces antibiotic exposure and patient length of stay (a 23% reduction in antibiotic exposure) No adverse safety signals associated with PCT-guided antibiotic therapy for sepsis PCT & Antibiotic Stewardship Monitor PCT levels Gain needed data to make better, more informed decisions Additional guidance for initiation and discontinuation of antibiotic therapy Improve prescribing practices to slow rise of resistant bacteria Support CMS guidelines for antibiotic stewardship and infection prevention So you can achieve the goal of giving antibiotics to the right patients, at the right time, for the right duration

Systematic Review

All tests were 2-sided, with a type I error set at 0.05