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This local iron overload in DSCs triggers ferroptosis through reduced GSH and glutathione peroxidase four levels with the concomitant increase in lipid and cellular ROS

In addition to their role in promoting breast cancer cell proliferation [67] and mediating inflammation [68], breast CAFs deposit collagen type I and fibronectin [58], secrete matrix metalloproteinases (MMPs) [69], and promote collagen crosslinking (e.g., via lysyl oxidase (LOX)) [70]

In clinical research, intra-articular injection therapy has shown significant efficacy and safety in treating knee OA

Among them, Cd, Pb, As, Hg, and Cr show highly toxic effects on plant growth, development, and productivity [5, 6, 10, 15]