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In a controlled experiment by Yu et al

Importantly, lysine acetylation occurs through both enzymatic mechanisms, mediated by acetyltransferases and deacetylases, and non-enzymatic mechanisms, particularly in metabolically active compartments such as the mitochondrial matrix where acetyl-CoA concentrations are high and the pH is slightly elevated 9,10

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However, viruses that replicate in the cytosol are short of raw material, i.e., nucleic acids, viruses gain a fitness advantage from supressing or escaping from the host immune system, and all viruses are under selective pressure to make the most efficient use of their small set of genes