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Methods: We used AAV-TBG-cre to specifically delete hepatocyte Cul3 in obese mice

The 30-bp deletion variant of LMP1, found in 89% of tumor biopsies, and EBER positivity (59%), especially among Naga individuals who consume smoked foods, suggest a region-specific viral mutation pattern (29), tobacco-betel quid chewing (OR = 7.0), and alcohol use (OR = 2.12) show strong associations, particularly when interacting with genetic variants like CYP1A1 TC/CC and GSTM1 null (31, 38) [19,22]

We then confirm these findings using the GEO database with clinical data from patients with cholangiocarcinoma in the GSE107943 dataset

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