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On the other hand GPx3 is negatively correlated with MAPK oncogenic signaling pathway (94), which suggests a potential antitumor effect in thyroid cancer, while a decrease in GPx3 levels predisposes to an increase in the size of primary tumors and the number of metastatic lymph nodes (95, 96)

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In contrast, the model group exhibited pronounced pathological changes, including marginal osteophyte formation, irregular articular surfaces of the femoral condyles and tibial plateaus, focal cartilage erosion with surface defects, osteogenic hyperplasia, cortical bone thinning, and rarefaction of the trabecular network

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