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[9] Depending on this modified state, FOXO4 binding affinity for DNA is altered, allowing for FOXO4 to regulate many cellular pathways including oxidative stress signaling, longevity, insulin signaling, cell cycle progression, and apoptosis

Phytochemicals have multiple mechanisms of action and are through to be less potent and to have a lower risk of adverse side effects compared to conventional anti-obesity medications, thus making them the preferred choice in the management of drug-resistant patients with obesity as a complementary or even primary therapeutic option [15]

Any over-activity or inhibition of these systems may lead to lesions in different organs