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The method involves chemical labeling of the 5-formylcytosine, conjugation to biotin for pull-down enrichment, removal of 5fC-free strands, and ligation to adaptors prior to PCR amplification

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Although these instruments have been subjected to feasibility, reliability, and validity testing, additional development and testing would be required prior to transforming the concepts reflected in the BIMS and CAM (for example, temporal orientation, recall) into fully specified measures for implementation in the LTCH QRP

They can be broken down in two ways: through proteolytic hydrolysis or proteasomal ubiquitination, leading to the breakdown of proteins into amino acids