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IGV-001 is a vaccine targeting GBM, designed based on the Imvax platform Goldspire

Regular injections, as prescribed by a healthcare provider, can help maintain consistent Vitamin B12 levels and optimize the benefits

Concurrently, elevated pyruvate kinase M2 (PKM2) expression upregulates Bcl-xL [59], while mesenteric adipose tissue (MAT) and lamina propria lymphocytes (LPL) show characteristic apoptotic dysregulation with increased Bcl-2 and decreased BAX expression [60, 61]

It then further converts to -ketoglutarate (-KG) through the action of glutamate dehydrogenase (GLUD) or transaminases, entering the tricarboxylic acid (TCA) cycle, generating reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2), and ultimately producing adenosine triphosphate (ATP)