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Recent advancements in single-cell multiomics techniques 207 , which can simultaneously profile the (epi)genome, transcriptome and other molecular layers, have been instrumental in inferring the intricate interplay among chromatin, transcription factors and genes generating a complex regulatory circuit represented as GRNs

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These results underscore the need for further research to explore the mechanisms underlying the roles of PA and vanin-1 in diabetes and cardiovascular health, as well as to assess the generalizability of our findings across diverse populations

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