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The amount of triamterene added to the 25 mg of hydrochlorothiazide in triamterene and hydrochlorothiazide tablets was also determined from steady-state dose-response evaluations in which various doses of liquid preparations of triamterene were administered to hypertensive persons who developed hypokalemia with hydrochlorothiazide (25 mg given once daily)

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25 A more recent Cochrane review of the pharmacologic treatment of low back pain (also not specific to lumbar spinal stenosis) found that NSAIDs, muscle relaxants, and opioids had a small effect on pain reduction, but use of muscle relaxants and opioids was complicated by a significant risk of adverse effects