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Later, vaccine strains were assessed in a natural host infection model where calves received 10 9 CFU oral dose of MAP wild-type or mutant strains at 2 weeks old

Furthermore, a reduction in spare respiratory capacity was specifically observed in SCC25 cells, suggesting a potential impairment in their ability to adapt to increased energy demands during rapid proliferation

However, the use of XAV939 reversed the increasing effect of Miln and Van on measured thresholds resulting in values that were significantly lower than those in their XAV939-free counterparts

Further development of these immunologic, pharmacological, and genetic tools will be critical in the future for clarifying the controversies surrounding the lactate transporters and lactate functions in the nervous system