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Wound macrophages as key regulators of repair: origin, phenotype, and function

5 (7), eaaw7243

Taken together, these data validate the structural model of the two binding sites, and show that the long helix provides the most binding affinity, while binding to the F-pocket provides a substantial enhancement of binding

393,394 Thus, the mechanisms underlying the regulatory role of SIRT1 in DNA repair and gene transcription in cancer development need further exploration