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BF_V3 showed the highest concentration, while the control variant and BF_V4 showed the lowest concentrations

These groups received intravenous treatments of oridonin, orid-liposome, orid-liposome-MAL, and TLR2 pep-orid-liposome at a dosage of 5 mg/kg (equivalent to the active ingredient of oridonin), with PBS serving as the control, administered every other day

The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results