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Organ-on-Chip: advancing nutraceutical testing for improved health outcomes

The antioxidant property of Sp was however, found to be insensitive to depletion of glutathione by BSO, which generally causes loss of cellular antioxidant function and higher ROS (Fig

Compared with the normal control group, mice treated with DHP exhibited the following characteristics: the proportion of cells in the G0/G1 phase decreased, the proportion of cells in the S phase increased, the positive rate of -gal decreased, the expression of telomerase increased, the expressions of p16INK4a and MMP-3 decreased, and the fluorescence expression of Lamin B1 in mice of the DHP 100 mg/kg group and the DHP 350 mg/kg group increased (Zhang P

Environmental stress induces excess ROS that can injure plant cells by oxidation of cellular components such as proteins, inactivate metabolic enzymes, DNA and lipids 8,9