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In severe cases, a vitamin B12 deficiency can cause more serious symptoms such as confusion, memory loss, and even psychosis

And for many participants, a fundamentally different relationship with food and body composition

However, as the definition of IC/BPS appears to be expanding from a bladder disease to a chronic pain syndrome, reliable new outcome measures will have to be developed

Methods A targeted literature search of experimental and clinical studies was performed, focusing on angiogenesis-related mechanisms in neurodegeneration and the effects of antiangiogenic compounds on neuronal and vascular function