gut diseases glutathione Impairment of intestinal synthesis in patients with inflammatory bowel disease Tea Polyphenol Epigallocatechin Gallate and

Oxidative stress: NRF2 induces antioxidant genes that reduce oxidative stress by minimizing the levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) (Ma, 2013)

doi: 10.1016/j.plaphy.2021.05.038 103 RahmanS.XuebinQ.YasinG.ChengH.MehmoodF.ZainM.et al

Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X

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