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113 Central Nervous System Drug Administration and the Blood-Brain Barrier Some speculate that strong selective pressure must have existed to allow such a complex structure as the BBB to evolve

In addition, increasing evidence highlights their noncanonical anti-inflammatory properties, as well as other nonimmune functions, including the promotion of adipose tissue browning and the enhancement of angiogenesis through extracellular HSP70 activity

3.4 Viral vectors Viral vectors serve as a type of delivery system that possesses natural transmembrane transport capabilities, and they have demonstrated potentials in achieving brain-targeted drug delivery across BBB by emulating the natural infection mechanisms of viruses (He et al., 2025