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The QCN-HS also exhibited histological evidence of dermal repair, including reduced inflammatory infiltration, organized collagen deposition, and enhanced vascular density, supporting the observed molecular changes

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Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig

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Cell culture Raw 264.7 cells (murine mononuclear macrophage cell line) were kindly provided by Cell Bank/Stem Cell Bank, Chinese Academy of Sciences

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