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Depletion of Methylfolate Directly Another way the body breaks the peroxynitrite cycle is by directly scavenging peroxynitrite using methylfolate.34 This results in oxidized methylfolate, which cannot be used until it has been regenerated back to its original form by ascorbic acid (vitamin C).36 This is another pathway that reduces folate levels, contributing to low thymidine levels and potential DNA strand breaks

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By Supporting the Elimination of Harmful Substances Folate, B6, and B12 vitamin supplements can help increase glutathione levels by supporting the elimination of certain substances that can emerge in the body and potentially cause harm