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While metabolic reprogramming towards increased glycolytic flux to favor increased cell proliferation is a recognized hallmark of cancer, functional mitochondria remain essential in maintaining malignant cell bioenergetics in particular tumors, including those of lung and brain [45-47]

Antioxidants 9(11):1088 Pandi-Perumal SR, Srinivasan V, Poeggeler B, Hardeland R, Cardinali DP (2007) Drug insight: the use of melatonergic agonists for the treatment of insomniafocus on ramelteon

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