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Enhanced expression of defense-related genes like GSTs during systemic infections could be also due to the silencing suppressor activity of the infecting virus, as shown for A

For instance, activating AMPK/SIRT1 pathways to enhance neuronal GSH precursor supply or targeting Nrf2-dependent antioxidant gene expression, particularly addressing SIRT1 hypofunction in Alzheimers disease, may optimize neuroprotective outcomes by addressing patient-specific metabolic vulnerabilities (Simon et al., 2020)

alpha-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction

Benefits of Glutathione Antioxidant Defense : Glutathione neutralizes free radicals, preventing cellular damage