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Consequently, CPs are frequently associated with a wide array of comorbidities, including endocrine deficiencies, visual disturbances, obesity, metabolic and cardiovascular derangements, sleep disorders and cognitive sequelae, all of which can negatively impact patients functional capacity and quality of life [5], leading to an increase in overall mortality (3- to fivefold higher than that observed in the general population [6])

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Monteiro-Soares, M., Boyko, E