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coli infection induced local changes in the peritoneum alone, not in the plasma or lungs ( Above all, advanced host types of machinery protect cells by detecting and preventing damage due to intrinsic and exogenous inferior substances, such as oxidative stress and toxins ( Keap1-Nrf2 Signaling Pathway The Keap1-Nrf2 regulatory pathway is a key mechanism for preventing cell damage by detecting intrinsic and exogenous stresses, such as oxidative stress, chemotherapy, and radiation, regulating gene expression to modulate various subsequent antioxidant functions ( Figure 2 ) ( via activation of the Keap1-Nrf2 signaling cascade (95)

(2015) 10:e0119316

This could be connected to EMS-induced senescence, endoplasmic reticulum stress, and oxidative stress in CGCs (73, 74)

Recent studies on Alzheimers disease models have demonstrated that hydrogen can mitigate neuroinflammation by inhibiting the NLRP3 inflammasome pathway, thereby reducing the expression of IL-1 and TNF- , and modulating microglial polarization