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C., Kowdley, K

Commonly co-administered agents include aromatase inhibitors (e.g., anastrozole or letrozole) to reduce estrogenic effects, selective oestrogen receptor modulators (SERMs

The IR usually progresses in silence and manifests clinically years after being present in the form of hyperglycemia, favoring atherogenesis and plaque progression in a curvilinear relationship with vascular disease, even in the absence of hyperglycemia ( 2 O 2 and O 2 activate stress-sensitive serine/threonine kinases such as JNK, IKK, and PKC, which phosphorylate IRS-1 at inhibitory serine residues (Ser307, Ser612), disrupting its interaction with the insulin receptor and promoting proteasomal degradation (Roden et al., 2017)