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Description

GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet

doi:10.3389/fvets.2022.936620 47

Mechanistically, inhibition of CD38 in vivo via apigenin leads to an increase in cellular NAD levels and activation of NAD-dependent enzymes, (e.g.SIRTUINs) [72]