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As shown in Figure 6, reporting the residual activity of LiTR after treatment with a fixed concentration (100 M) of the compounds, the fragments have a low but evident effect on protein activity, in line with the general behavior of fragments, whose affinity for the target is usually in the millimolar range due to the small size of these compounds that limits the number of possible interactions

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The role of mitochondrially derived ATP in synaptic vesicle recycling