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3510-C ALCOHOL MODULATES HEPATIC AMYLOID ETA AND LIPID METABOLISM IN APP/PS1 MOUSE MODEL OF ALZHEIMERS DISEASE Veronika Brezani, Radhika Joshi, Marti Ortega-Ribera, Mrigya Babuta, Yanbo Wang and Gyongyi Szabo, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Background : Chronic alcohol abuse impairs liver function and increases the risk of dementia

In cells exposed to 10 M BSO, a -glutamyl-cysteine ligase (GCL) blocker, mBBr fluorescence was significantly reduced to 51 4% ( n = 11) as compared to untreated cells

Low-dose aspirin is also being investigated as a possible therapy for preventing heart attacks in people with high Lp(a)

Additionally, they noted overexpression of Gal-3 mRNA in cystinosis knock-out mice, and the inability to clear Gal-3 efficiently