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*Correspondence: Wolfram-Hubertus Zimmermann, [email protected] These authors have contributed equally to this work This article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This overview is based on previously conducted studies and does not contain new data/results of human participants or animals performed by the authors

This scenario is changing in recent decades, when advances in crystallization technologies and automation of beamlines have allowed a greater flow of data collection, revealing XRD as one of the most powerful tools among the biophysical methods currently in use for fragment screening 89

Sutherland ER, Crapo JD, Bowler RP