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The concept draws from hormesis, a biological phenomenon where low-dose exposure to a substance produces beneficial effects while higher doses might produce neutral or even counterproductive outcomes

A 2006 study published in the Journal of Clinical Endocrinology and Metabolism examined CJC-1295 in healthy adults and found sustained, dose-dependent increases in GH and IGF-1 levels over several weeks

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This bidirectionality may explain why some nutrient interventions fail [e.g., vitamin B12 supplementation is ineffective in patients with gut microbiota dysbiosis (149)]