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This may facilitate the digestion of cellulose in the hindgut, and also suggests that, despite differences in microbial composition between the rumen and intestine (Zou et al., 2020), like communication between the upper and lower intestinal tracts, the effects of changes in the dominant bacteria in the rumen are transmitted to the intestinal tract (Steele et al., 2016)

Clinical investigation to support new uses generally requires an Investigational New Drug (IND) application with appropriate chemistry, manufacturing, and controls, nonclinical safety, and human data

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages