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99,100,101 A study analysing 21 brain metastases and their matched primary breast cancer showed that BCBM tends to have high genomic-aberration-based-homologous recombination deficiency (HRD) scores compared with their primary tumour counterparts, which indicates that brain metastases might be more sensitive to PARP inhibitors than their corresponding primary tumours

When ROS levels become too high, LSCs induce mitophagy to limit ROS production, or else they will be pushed out of quiescence and cell death pathways will be activated (61, 86)

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