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Despite the fact that the technique concurs to the treatment of a relatively extended region of hypopigmentation rapidly, a split-thickness skin graft has some disadvantages, as well as an insufficient color and texture correspondence between the treated and donor area: disturbance of sensation within the recipient area could develop displacement of the grafts, milia formation, perigraft depigmentation, and imperfect scarring at recipient or donor areas [128,129]

Evening dosing (30 to 60 minutes before sleep) is strongly recommended so that nausea and flushing peak during sleep rather than during the day

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