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Taken together, PNPLA2-mediated intracellular lipolysis promotes crosstalk between cancer cells and adipocytes and subsequently promotes tumor progression and aggressiveness

Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

Patients with rare genetic conditions affecting B12 metabolism are typically managed by specialists who may prescribe high-dose hydroxocobalamin

[16] [18] Current clinical guidelines recommend caution and individualized decision-making, given the lack of robust safety data for high-dose injectable vitamin C in pregnancy and lactation