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Angiogenesis and Wound Healing Models: In rodent excisional wound, burn, and ischemic flap models, co-administration promoted faster wound closure, greater vascularization (upregulated VEGF), increased keratinocyte and fibroblast migration (via TB-500s actin-binding effects), and superior granulation tissue formation

Shank3 knockout mice exhibit reduced GABA receptor densities in thalamocortical circuits [98]

Further, one commenter suggested that when selecting measures under this proposal, CMS should view performance rates for traditional MIPS independently from MVPs while another commenter requested that CMS remove the 7-point cap for a specified timeframe to ensure stability for clinicians