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Third, l-ARG supplementation is generally less costly than some reference/equivalent pharmaceutical formulations or dosages of PDE5i, therefore being more suitable for long daily treatment regimens

In recent years, vascular diseases have become the leading cause of mortality worldwide [1]

Given that supplementing diets with pro- or pre-biotics typically increases gut microbial fatty acid production, and that fats are fatty-acid compounds, it is interesting to note that an unsupplemented diet poor in carbohydrates, no more than adequate in protein, but high in fats, has repeatedly been found to produce similar benefits

doi: 10.1186/s13020-016-0118-5 80 DhandayuthapaniSPerezHDParoulekAChinnakkannuPKandalamUJaffeMet al