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Evidence from germ-free mouse models demonstrates an essential role for the microbiota in ENS maturation and function, with the absence of commensal colonization leading to reduced enteric neuronal density, impaired intestinal peristaltic reflexes (106108), and defective recruitment of EGCs into the intestinal mucosa during development, ultimately compromising neuroimmune integration and homeostatic regulation (109)

Initially 6 injections are given over 2 weeks .Different patients require different regular maintenance of the injections to keep them free of symptoms ( anything from daily to once every 3 months)

Oral Recombinant Methioninase (O-rMETase) Is superior to Injectable rMETase and Overcomes Acquired Gemcitabine Resistance in Pancreatic Cancer

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