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This is why trial protocols pair the drug with a calorie deficit plus physical activity, and why resistance training and protein intake come up in every clinical discussion of these medications

3336 Mitochondrial dysfunction manifests in multiple aspects, including mutations and deletions in mitochondrial DNA (mtDNA), disrupted calcium homeostasis, depolarization of the mitochondrial membrane, abnormal fusion and fission processes, impaired mitochondrial biogenesis, and oxidative stress

The more progressed the deficiency is, the more detrimental it may be to an individual with Hashimotos

Deprescribing inappropriate or unnecessary medications impacts clinical outcomessuch as reduction in hospitalizations, ED visits, falls and overall healthcare costsmitigates ADEs, and improves quality of life