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Procedures such as gastric bypass or sleeve gastrectomy can produce substantial, sustained weight loss and dramatic improvements in PCOS symptoms, insulin resistance, and fertility outcomes

Other supportive evidence is the correlation of the rate of transport of a given substance with transcellular electrical resistance, in which lower transport rates of substances assumed to be transported paracellularly are observed in high-resistance, tight epithelia, although electrical resistance and the transport of marker molecules do not always coincide

Apperloo EM, Neuen BL, Fletcher RA, et al

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