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People with diabetes who take metformin are at higher risk of developing B12 deficiency because this drug can reduce the absorption of vitamin B12 in the body B12 deficiency impairs motor and sensory nerve function

After 1 year of treatment, the patients biological age was reduced by 7.9 years (from 75.93 to 68.03), and his telomere length increased from 6.45 to 6.59 kb (Table 3)

For the elderly, managing Vitamin B12 levels is critical as a deficiency is more prevalent among this population, often due to malabsorption and dietary factors

To date, there is still no effective treatment for ALS, and the two currently available drugs, riluzole and edaravone, only extend survival of ALS patients by few months [78,79,80,81,82,83]