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Next, we found that CXCL10 directly bound to IL18R1 to impair ovarian function through three pathways: inducing ovarian fibrosis through p-JNKp-JUN COL1A1, promoting primordial follicle overactivation through p-AKTp-FOXO3A, and increasing ovarian inflammation through p-P65 IFN

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The mean values of the smoking index (pack-years) were significantly higher in the patients (53.75 15.98) compared to the control (16.50 8.10)

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doi: 10.1016/j.envres.2016.07.011 93 MorganMDeorajAFeltyQRoyD

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