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Both the host and fungi produce ROS, use conserved mechanisms to detoxify ROS, and leverage ROS in their local environment to mediate defense mechanisms

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The basal levels of ROS in the leukocytes in whole blood can be determined using the dihydroethidium and dichlorodihydrofluorescein-diacetate probes (Table 2)

Similarly, treatment with lactate dehydrogenase inhibitors (LDHi) reduces tumor cell glucose uptake and expression of the glucose transporter GLUT1, improving the tumor-killing function of T cells and dampening Treg immunosuppressive activity