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Sleep Disruption Declining progesterone and fluctuating estrogen disrupt sleep architecture

2023 Jul;23(4):337-346

The systemic inhibition of GSH synthesis by L-buthionine-S-R-sulfoximine (BSO, In the cerebellum, EAAT3 up-regulation and increased GSH levels were associated with an earlier activation of the NGF/TrkA and mTOR signaling pathways in neurons ( Nerve growth factor is a neurotrophin (NT) that regulates neuronal development, differentiation, plasticity, cell death and survival ( In the human and murine CNS, NGF- and TrkA-positive regions correlate with the anatomical distribution of cholinergic neurons in the basal forebrain and striatum (Yamamoto et al., 1996)

SELENOI is expressed in multiple tissues, but within the brain it is particularly expressed within the cerebellum (Horibata and Hirabayashi, 2007)