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[8] Others Some illicit substances are known to interact with Lexapro, including the following substances, which may increase the risk of serotonin syndrome: [5] Methamphetamine Cocaine MDMA (ecstasy) LSD Ayahuasca Psilocybin (magic mushrooms) Other legal substances or supplements that can interact with Lexapro include: [5] St Johns wort Nutmeg Panax ginseng Syrian rue Recognizing dangerous symptoms Dangerous symptoms that may occur when Lexapro interacts with other substances include: [1][2] Fever Extreme confusion Changes in mental status Oversedation Drowsiness and dizziness Impaired cognitive functioning, including poor memory and concentration Changes in heart rate and blood pressure Seizures Hallucinations Loss of consciousness Shaking Vomiting If any of these symptoms occur, contact a medical professional immediately, as this may indicate signs of drug interactions, overdose, or serotonin syndrome