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1A Schematic illustration of pathways regulated by NNMT, including the NAD+ biosynthesis salvage pathway starting from NA as a precursor that feeds into energy metabolism, methionine cycle that regulates intracellular SAM concentrations and thus cellular epigenetic modifications and polyamine flux, and clearance of NA by conversion to 1-MNA and excretory products

You might have heavy periods if you: Soak through a pad or tampon every hour for several hours Use two pads at once to control bleeding Bleed for more than 7 days Pass clots larger than a 10p coin Have to change protection during the night Avoid activities because of your period What causes heavy periods

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