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References 1 AchamrahN.DechelotteP.CoeffierM

Thus, SIRT1 can deacetylate LKB1 resulting in AMPK activation, closing a positive feedback loop between AMPK and SIRT1

Muscle strength was objectively quantified using the hand grip strength test, whereas fatigue severity and its impact on daily life were subjectively assessed via the Patient-Reported Outcomes Measurement Information System Fatigue Computer-Adaptive Test [188, 189]