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Supporters describe it as working beyond the gut

doi: 10.1007/s12035-020-01975-6 140

We replicated both of these findings in human lung fibroblasts, which are the major interstitial cells that maintain tissue structural integrity by sculpting the connective tissue

Low carbohydrate intake causes physiological ketosis in patients with polycystic ovary syndrome, which reduces circulating insulin levels, lowers IGF-1 levels, and inhibits stimulation of androgen production, including in the ovaries and adrenal glands