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Disclaimer:Nekothione is generally safe to intake, for up to 14 years old and above

Cladribine, gemcitabine, lovastatin and tamoxifen have an inhibitory effect on melanoma cell lines in vitro, also in combination with conventional targeted kinase inhibitors To identify the most promising drug candidates for in vitro testing, we filtered the predicted drugs based on their predicted efficacy, prior evidence from high-throughput CRISPR [34] and drug screens [35], IC 50 values in melanoma and other cancer types, known metabolic targets, mechanisms and availability of clinical trial data in phase II or higher (Table 2 and Supplementary File 2)

The control of ROS involves the glutathione (GSH) balance, owing to antioxidant activity

doi: 10.1371/journal.pone.0079316 121 MirandaERDeyCS