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In contrast, ALA exerts its principal effects on mitochondrial metabolism through its established role as an essential cofactor for mitochondrial -ketoacid dehydrogenase complexes, including pyruvate dehydrogenase and -ketoglutarate dehydrogenase, thereby facilitating efficient entry of glycolytic substrates into the tricarboxylic acid cycle and sustaining electron transport chain activity under oxidative stress conditions

In comparison, the raw curcuminoid powder had a curcumin content of 76.82% w/w (54)

624 In addition, the ferroptosis inhibitor Fer-1 significantly inhibits oxidative lipid damage and ferroptosis in neurons of HD cell models

Supporting the bodys natural defenses and ability to adapt to daily stressors is essential for sustained wellness