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doi: 10.1016/0041-008x(89)90283-4

The interconnections between proteins and their functions were visually represented using a Circos plot, created with the BioLadder online analysis software ( Western blot Sciatic nerve tissues were homogenized using an electric tissue homogenizer (Fluka, Inc.) with a 10 s on/10 sec off cycle on ice

In addition, proteomic studies using different animal models of depression have revealed alterations in specific proteins involved in OXPHOS and also confirmed the effect of antidepressant treatment in the expression of these proteins (reviewed in In depressed patients, most of the differentially expressed proteins are involved in cellular assembly, organization, function, and maintenance, as well as cardiovascular system development and function, but they are mainly related to deregulation of energy metabolism pathways (Martins-de-Souza et al., 2012)

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